Beilstein J. Org. Chem.2019,15, 1984–1995, doi:10.3762/bjoc.15.194
wilfordiiHookF; triptolide; Introduction
Triptolide (1, Figure 1) is the first diterpenoid triepoxide isolated from TripterygiumwilfordiiHookF. (TWHF) in 1972 [1]. It has attracted an ever-increasing attention due to its intriguing structural features and various promising pharmacological activities
and multiple promising biological activities. In this review, progress in the total syntheses of triptolide are systematically summarized. We hope to gain a better understanding of the field and provide constructive suggestions for future studies of triptolide.
Keywords: total synthesis; Tripterygium